Human Papillomaviruses Oncoproteins
نویسندگان
چکیده
منابع مشابه
Interaction of viral oncoproteins with cellular target molecules: infection with high-risk vs low-risk human papillomaviruses.
Persistent infection by a subgroup of so-called high-risk human papillomaviruses (HPVs) that have a tropism for mucosal epithelia has been defined as the cause of more than 98% of cervical carcinomas as well as a high proportion of other cancers of the anogenital region. Infection of squamous epithelial tissues in the head and neck region by these same high-risk HPVs is also associated with a s...
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O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) increases O-GlcNAc modification (O-GlcNAcylation), and transcriptional co-regulator host cell factor 1 (HCF-1) is one of OGT targets. High-risk Human Papillomaviruses (HPVs) encode E6 and E7 oncoproteins, which promote cervical cancer. Here, we tested whether O-GlcNAc modification of HCF-1 affects HPV E6 and E7 expressions and tumorigene...
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A combination of functional studies on human papillomavirus (HPV) oncoproteins and epidemiological studies on persistence of HPV infection firmly established a role for HPV in the etiology of cervical cancers. Understanding the viral life cycle of HPVs has been more difficult. In this issue of Genes & Development, Wang et al. (pp. 181 - 194) describe an efficient method to propagate infectious ...
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Bovine papillomaviruses (BPVs) are recognized as the causal agents of economical relevant diseases in cattle, associated with the development of tumors in skin and mucosa. The oncogenesis process is mainly associated with different viral oncoprotein expressions, which are involved in cell transformation. The expression and characterization of recombinant viral oncoproteins represent an attracti...
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Papillomaviruses induce benign and malignant epithelial tumors in vertebrates through the action of virally encoded oncoproteins such as E6. Recent studies of human and animal E6 proteins determined the three-dimensional structure of E6 when bound to LXXLL peptides derived from E6-targeted cellular proteins. The interaction between diverse E6 proteins and their different cellular targets has re...
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تاریخ انتشار 2017